WHY NEUROMODULATION BY FOCUSED ULTRASOUND?
Transcranial NeuroFUS provides spatial resolutions that are higher than other noninvasive neuromodulation methods.
The top image to the right illustrates the spatial distributions of a typical electric field produced by TMS. The spatial distribution (resolution) of peak electric field strengths produced by TMS extend up to several centimeters in some directions.
The image at the bottom-right illustrates that transcranial NeuroFUS can significantly modulate physiological EEG activity in the cortex of healthy humans with precise spatial resolution (Legon et al, Nature Neuroscience, 2014). As shown, the shape of the 0.5 MHz transcranial ultrasound focus is an ellipsoid, equivalent to the CTX-500 (see table ahead). This method has been reproduced by others showing focused neuromodulation is safe, confers high spatial resolutions, and is readily compatible with electrophysiology and imaging methods such as EEG and fMRI.