Why Neuromodulation by
Focused Ultrasound (NeuroFUS)?

NeuroFUS is a turnkey system that delivers low-intensity (nonthermal) focused ultrasound (FUS) for transcranial brain or transdermal nerve modulation to support neuroscience research studies as well as medical device research and development.  NeuroFUS represents a state-of-the-art, noninvasive neuromodulation method.  NeuroFUS hardware is electromagnetically and mechanically compatible with other modern neuroscience methods and neurotechnologies. These compatible neurotechnologies include: human behavior, optical imaging (including fNIRS), EEG, AR/VR immersion or stimulation, peripheral nerve stimulation including VNS, and other neuromodulation methods such as tES, tDCS, tACS, and TMS.

Both NeuroFUS versions are powered by Sonic Concepts, Inc.’s Transducer Power Output™ (TPO™) drive electronics, commander USB interface and focused annular array transducer technology.  Both versions of the turnkey system provide ultrasound pulse capability for both cortical and peripheral stimulations with dynamic focal depth adjustment for treatment precision.  Each unit is calibrated and comes with a Certificate of Conformance.

NeuroFUS PRO comes equipped with the Software Development Kit (SDK) and safety peripherals, and includes a workshop, training and consulting package and access to integration packages including TMS and neuro navigation systems.

The NeuroFUS system is not an FDA-evaluated medical device. The system is for research purposes only and is not intended for the treatment of any medical disorder or condition.

WHY NEUROMODULATION BY FOCUSED ULTRASOUND?

Transcranial NeuroFUS provides spatial resolutions that are higher than other noninvasive neuromodulation methods.

The top image to the right illustrates the spatial distributions of a typical electric field produced by TMS. The spatial distribution (resolution) of peak electric field strengths produced by TMS extend up to several centimeters in some directions.

The image at the bottom-right illustrates that transcranial NeuroFUS can significantly modulate physiological EEG activity in the cortex of healthy humans with precise spatial resolution (Legon et al, Nature Neuroscience, 2014). As shown, the shape of the 0.5 MHz transcranial ultrasound focus is an ellipsoid, equivalent to the CTX-500 (see table ahead). This method has been reproduced by others showing focused neuromodulation is safe, confers high spatial resolutions, and is readily compatible with electrophysiology and imaging methods such as EEG and fMRI.

HOW DOES NEUROFUS WORK?

The NeuroFUS system uses the TPO drive electronics system comprised of four discrete RF signals with independent transmit agility.  The TPO uses high-fidelity amplifier technology to produce spectrally pure sinusoidal signals.  Each channel supports transmit modes ranging from a single cycle pulse to large bursts.

The NeuroFUS transducer is comprised of four sub-apertures, low-loss cables, and matching networks.  The four discrete amplified sinusoidal voltage waveforms pass through the matching network and cable and into the respective sub-aperture of the transducer, which converts voltage to pressure.

The integrated system uses time delay to electronically steer the acoustic focus along the axis with micrometer resolution.  Acoustic intensity and beamforming calibration are performed within a free field environment.  The user may implement aberration and attenuation corrections as determined by their internal review board.

To properly couple the transducer’s spherical radiating surface to the patient, a solid water coupling material fills the concavity of the spherical bowl until the exit plane of the transducer is flat. With the solid water coupling material in intimate contact with the patient, the acoustic pressure is able to propagate to the subject’s treatment site.  The FUS transducer is equipped with a handle for manual positioning about the subject’s surface.

SAFETY

The NeuroFUS system uses the TPO drive electronics system comprised of four discrete RF signals with independent transmit agility.  The TPO uses high-fidelity amplifier technology to produce spectrally pure sinusoidal signals.  Each channel supports transmit modes ranging from a single cycle pulse to large bursts.

The NeuroFUS transducer is comprised of four sub-apertures, low-loss cables, and matching networks.  The four discrete amplified sinusoidal voltage waveforms pass through the matching network and cable and into the respective sub-aperture of the transducer, which converts voltage to pressure.

The integrated system uses time delay to electronically steer the acoustic focus along the axis with micrometer resolution.  Acoustic intensity and beamforming calibration are performed within a free field environment.  The user may implement aberration and attenuation corrections as determined by their internal review board.

INTELLECTUAL PROPERTY

NeuroFUS is licensed through IST.

  • Issued, USA Patents 9403038, 8858440, and 8591419
  • EU EPO Patents 2310094 and EPO 2496307
  • China Patents ZL2009 8 0135241.4
  • Japan Patents 6061678, 5879402, and 5597198
  • Israel Patents 210642 and 219584
  • Other USA and International Patents Pending

LIMITATIONS & UPGRADES

  • The NeuroFUS system is not CE marked and is not agency compliant.
  • The NeuroFUS system does not offer a floating ground transducer with a fully insulated shell that will be tested up to 2 MOPP.
  • The NeuroFUS system does not include real-time power monitoring using Sonic Concepts’ RFWattmeter.
  • The NeuroFUS system shall pass the customer’s internal review board or equivalent before use on humans.
  • All NeuroFUS transducers are upgradable to be MR-compatible.

Learn more about how to purchase our NeuroFUS products.

REQUEST A QUOTE
CONNECT WITH AN EXPERT
REQUEST A QUOTE
CONNECT WITH AN EXPERT

NeuroFUS is powered by Sonic Concepts, Inc.