Transcranial focused ultrasound (tFUS) is a revolutionary technique grounded in decades of experience with focused ultrasound technology. Instead of electric or magnetic stimuli, tFUS uses finely tuned sound waves that can be concentrated at a precise target anywhere in the brain. As a result, tFUS offers unprecedented spatial resolution and control compared to other noninvasive neuromodulation methods. tFUS can also target deeper brain regions compared to other methods.
Additionally, tFUS can controllably stimulate or inhibit specific nerve activity, depending on exact ultrasound pulse parameters, for example, intensity or frequency.15 This specificity offers researchers unprecedented control and targeting capabilities as well as revolutionary precision and resolution. By contrast, tES and TMS offer limited control and specificity.
Given the extraordinary capabilities of tFUS, it promises to offer novel treatments for a wide variety of neurologic conditions, from chronic pain and memory loss to psychological disorders and insomnia. What’s more, since tFUS produces signals that excite muscle contractions and activate specific brain regions, it is poised to become a revolutionary tool for high-resolution brain mapping.